Une corneille seule n'est pas une corneille.
Une corneille ne tue jamais une autre corneille.
Dans un futur proche ravagé par la pollution, un vieil homme nous raconte qu'une Corneille nommée Dar Duchesne - la première de tous les temps à avoir porté un nom - lui a raconté ses nombreuses vies et morts au pays de Kra...
Cet ouvrage est une réédition numérique d'un livre paru au XXe siècle, désormais indisponible dans son format d'origine.
This book presents the state of the art of biostatistical methods and their applications in clinical oncology. Many methodologies established today in biostatistics have been brought about through its applications to the design and analysis of oncology clinical studies. This field of oncology, now in the midst of evolution owing to rapid advances in biotechnologies and cancer genomics, is becoming one of the most promising disease fields in the shift toward personalized medicine. Modern developments of diagnosis and therapeutics of cancer have also been continuously fueled by recent progress in establishing the infrastructure for conducting more complex, large-scale clinical trials and observational studies. The field of cancer clinical studies therefore will continue to provide many new statistical challenges that warrant further progress in the methodology and practice of biostatistics. This book provides a systematic coverage of various stages of cancer clinical studies. Topics from modern cancer clinical trials include phase I clinical trials for combination therapies, exploratory phase II trials with multiple endpoints/treatments, and confirmative biomarker-based phase III trials with interim monitoring and adaptation. It also covers important areas of cancer screening, prognostic analysis, and the analysis of large-scale molecular data in the era of big data.
This book provides seven studies that address major issues such as the human rights and human security nexus, gender aspects of human security, ethical and environmental challenges, human security as a basic element for a policy framework, the human security agenda developed by the Human Security Network, and debates on human security within the United Nations. Building on its variety of themes, the book takes account of the complexity and scope of the concept of human security, and proposes thereby to refresh and enrich discussion Contributors are internationally renowned experts in the different subfields of human security Offers an overview of current trends and insights on what is at stake if the international community is to maintain the momentum created a few years ago when the concept of human security emerged Designed to help both newcomers and experts in the field of human security Readers will find inspiration in the new developments of a concept that aims to shape practical action to meet the needs of the most vulnerable