Currently, available information on pediatric and adolescent diabetes is limited to chapters in larger books covering the broader topic of pediatric endocrinology, and these do not have the space to delve into specific topics. This concise, timely book contains everything that a practicing provider needs to know in order to provide comprehensive, up-to-date care for children and adolescents with diabetes, from the latest methods for diagnosing various types of diabetes to integrating cutting-edge technology in the care of this patient population. Initial management, the use of insulin pumps, continuous glucose monitoring, and automated insulin delivery are discussed in detail, as are nutrition therapy, exercise, psychosocial challenges, acute and long-term complications, and future directions for treatment and research. Further, this book provides clinicians with guidelines for the implementation of best practices as outlined by leading associations such as the American Diabetes Association (ADA) and International Society of Pediatric and Adolescent Diabetes (ISPAD).
The Yale Children's Diabetes Program has been ranked among the best in the United States, including clinicians and researchers who are world-renowned for their efforts in improving the care of children with diabetes. This wealth of knowledge and experience positions the author team well as experts in this field.
This book is a comprehensive reference on diffuse cystic lung diseases (DCLDs). DCLDs are a group of pathophysiologically heterogenous processes that are characterized by the presence of multiple spherical or irregularly shaped, thin-walled, air-filled spaces within the pulmonary parenchyma. In recent years, tremendous advancements have been made in these diseases leading to improved understanding of the underlying pathophysiology, and improved outcomes with targeted therapies. The authors, who are leading experts in the field, delineate DCLDs as a separate category distinct from other interstitial lung diseases, and have created this textbook specifically dedicated to this disease group.
This book begins with a chapter introducing the definition and classification of DCLDs. Subsequent chapters address the pathogenic mechanisms underlying pulmonary cyst formation and provide a detailed overview of the radiological and pathological features of DCLDs. The common as well as uncommon causes of DCLDs are comprehensively reviewed in individual chapters, as are the varied clinical presentations and extrapulmonary manifestations, and approaches to management and treatment. The book culminates in a final chapter that presents a practical algorithmic approach to diagnosis that progresses from least invasive to most invasive approaches. This textbook provides a one-stop, comprehensive and integrated, clinical, radiologic, and pathologic overview of DCLDs that will be as useful to the practicing clinician as it is to the clinical investigator.
The hypothalamus is an anatomically small but functionally important part of the brain. In functional and pathophysiological terms, the hypothalamus represents the intersection of several areas of clinical and medical expertise. The human hypothalamus can be astutely referred to as the crossroad of endocrinology, psychiatry, neurology and neurosurgery. Because of its involvement in myriad physiologic functions and the varied ways disorders involving it can manifest, hypothalamic disease can initially come to medical attention in widely disparate settings and with widely different clinicians. Therefore, the detection and proper care of hypothalamic dysfunction and disease often requires carefully coordinated multidisciplinary care.
This volume fills a significant void in the medical professional community, comprehensively presenting the scope of hypothalamic structure, function, dysfunction and disease to cater to the various clinical, teaching and research professionals that have a stake in this part of the human brain. This text captures in one place all the information that practicing clinicians, clinician scientists, and researchers need to be adequately informed about various aspects of the hypothalamus in all its complexity. It is comprehensive and broad in scope so that it provides relevant reference information for the wide range of professionals involved in the pre- and post-mortem detection, diagnosis, characterization, care and management of various hypothalamic disorders and diseases in addition to providing a sound anatomic and physiologic foundation of the normal human hypothalamus. The Human Hypothalamus can be used to differing degrees by medical professionals and students alike, finding utility for interested general clinicians, medical school and allied health professional teaching faculty as well as subspecialists in domains as wide as neurosurgery, neuroendocrinology, clinical psychiatry and neuro-oncology.
Since the creation of the American Board of Clinical Lipidology, many clinicians have wanted an up-to-date, comprehensive reference on lipidology. Now, for the first time, clinicians can find such a reference in Therapeutic Lipidology. This volume will provide practicing clinicians with a focused and intensive but useable source of information on the identification and management of dyslipidemias. Among the topics discussed in this groundbreaking text are lipoprotein metabolism, pharmacological therapy for cardiovascular disease, thiazolidinediones on serum lipoproteins, hypertriglyceridemia, dyslipidemia and obesity, dyslipidemia in children, and much more.
The pace of scientific and clinical advances in lipidology is astounding. This reference will serve as a lifelong stimulus to the reader to continue to learn about the ever changing and fascinating field of therapeutic lipidology. Comprehensive and cutting-edge, Therapeutic Lipidology will empower readers to improve and extend the lives of the patients they so conscientiously serve.
This book offers a comprehensive review of the most common infectious diseases that affect the nervous system. Written by international experts, it provides a guide to clinicians for accurately diagnosing and treating these challenging syndromes.
Organized into six sections, the book presents didactic, up-to-date information on the following topics relating to central nervous system (CNS) infections: diagnosis and evaluation of the patient, bacterial, viral, fungal and mycobacterial infections, disorders of the spinal cord, and a myriad of miscellaneous infections. Chapters specifically reflect and look to resolve the common obstacles clinicians face in the field, such as having unknown etiologies on the majority of CNS infections, insensitive and slow microbiological techniques, an increasing number of immunosuppressed individuals with atypical presentations and pathogens, and a lack of standardized diagnostic algorithms.
A complex yet accessible addition to the Current Clinical Neurology Series, Neurological Complications of Infectious Diseases invaluably examines a wide range of infections that have neurological complications and sequelae.
Collaboratively authored by international experts and innovators, this book serves as a comprehensive introduction to flexible bronchoscopy in children, a guide to normal and abnormal bronchoscopy findings, and as the first pediatric bronchoscopy text to describe the array of innovative technologies now being utilized in advanced diagnostic and interventional bronchoscopy programs.
Flexible bronchoscopy is a core clinical service provided by academic pediatric pulmonary medicine programs and a critical skill that trainees are expected to develop. The role of flexible bronchoscopy in the care of children with disorders of the respiratory tract has evolved rapidly over the past decade due to technological advances in diagnostic and therapeutic instruments. While many of these tools were designed for adult patients, pediatric pulmonologists have adapted them to meet the unique needs of children.
The book is organized into three sections: the history and fundamentals of flexible bronchoscopy; the role of flexible bronchoscopy in evaluation of pediatric respiratory tract disorders; and advanced diagnostic and interventional bronchoscopy. Throughout, images and videos enhance the text and provide invaluable perspective.
This is an ideal guide for practicing pediatric pulmonologists and trainees, and will also prove useful to pediatric anesthesiologists, intensivists, otolaryngologists and respiratory therapists.
This book is a guide to the research, findings, and discussions of US and international experts on climate change and respiratory health. Since the publication of the first edition, climate change has been increasingly acknowledged as being directly related to the prevalence and incidence of respiratory morbidity. Evidence is increasing that climate change does drive respiratory disease onset and exacerbation as a result of increased ambient and indoor air pollution, desertification, heat stress, wildfires, and the geographic and temporal spread of pollens, molds and infectious agents. This second edition is fully updated to include the latest research by international experts on topics such as heat waves causing critical care-related diseases, climate-driven air pollution increases, and high-level ozone and ozone exposure linked to idiopathic pulmonary fibrosis, lung cancer, and acute lower respiratory infection. Seven new chapters have also been added on extreme weather and agricultural safety in California; desert dust effects on lung health; climate policy and the EPA; California's integrated approach to air quality and climate change; integrating climate change, the environment, and sustainability themes into professional health science courses; and the role of the physician as climate advocate. This is an ideal guide for all pulmonologists and health professionals treating patients with pulmonary disease.
This book is a clinical guide to controversial and emerging topics in pulmonary hypertension. There are multiple challenges and unanswered questions encountered by clinicians that evaluate, diagnose and treat patients with suspected or confirmed pulmonary vascular disease. This book provides a deep dive into the diagnosis and therapeutics of pulmonary hypertension supported by the literature and balanced with personal clinical experience. Expert authors have chosen these specific topics to address issues where uncertainty and/or controversy exists as well as highlight areas that are just being incorporated into clinical practice. These topics include: exercise pulmonary hypertension, sickle cell disease and pulmonary hypertension, and sarcoid pulmonary hypertension, among many others. Chapters address the diagnostic and treatment dilemmas posed by these various clinical entities through literature review, sharing of expert opinion, and review of recent guidelines and their applicability to the multiple different nuanced presentations of pulmonary hypertension. This is an ideal guide for pulmonologists, cardiologists, and other specialty practitioners caring for patients with pulmonary hypertension.
This book presents an up-to-date and comprehensive review of female contraception, offering an extensive overview of contraception types, including oral, injectable, emergency, and various cervical barrier contraceptives. It also discusses behavioral and sterilization methods of contraception as well as the clinical effectiveness, advantages, disadvantages, side effects, and mechanisms of action of each method.Now in its fully revised and expanded third edition, this text includes seven new chapters that address specific clinical issues that healthcare providers face daily. These issues include patients with medical problems, perimenopausal women, the adolescent population, post-pregnancy patients, patients with bleeding problems, fibroids or hyperplasia, obese patients and patients with acne or hirutism. There is also a new chapter dedicated to contraceptive methods that are currently in development. Each chapter reviews the correct use of the individual method, the most appropriate candidates, timing of initiation, red flag contraindications, risks and benefits, method of action, handling side effects, non-contraceptive benefits, switching methods and the CDC Medical Eligibility for the method. Importantly however, there is a new emphasis placed on standardized evidence-based practice recommendations incorporating the most recent US Selected Practice Recommendations and rationale as published by the US CDC. Written by experts in the field, The Handbook of Contraception, Third Edition, is a valuable resource for obstetricians, gynecologists, reproductive medicine specialists and primary care physicians.
This book focuses on the subsets of soft tissue tumors that show adipocytic, vascular or skeletal muscle differentiation. It reviews the surgical pathologists' approach to diagnosing soft tissue tumors guided by vital morphological and immunohistochemical data in the differential diagnosis of this family of tumors. Written by experts in the field, the text contains a concise yet comprehensive summary of the current status of the field that helps guide diagnosis and patient management, and stimulates investigative efforts. The book is filled with high-quality drawings of the salient histologic features of these various tumors, alongside photomicrographs and tips and tricks that help the relatively untrained or inexperienced eye to recognize the various structures or cell types that comprise each of these lesions. This innovative approach seeks to make recognition of these tumors easier.
Adipocytic, Vascular and Skeletal Muscle Tumors serves as a valuable resource for pathologists, oncologists, surgeons, and researchers dealing with and interested in these complex and challenging tumors.
This book is a comprehensive guide to the diagnosis and management of all stages of pulmonary embolism, starting with acute and ending with chronic thromboembolic pulmonary hypertension. Acute pulmonary embolism (PE) is responsible for 150-250,000 hospitalizations and 60-100,000 deaths each year in the United States, making it the third most common cause of cardiovascular death. Acute PE spans a wide spectrum of clinical outcomes mainly based on the right ventricle's (RV) capacity to tolerate strain. There have been many recent advances in the field of PE, including guidelines on classification and risk stratification, anticoagulation, as well as evolving areas in treatment options and follow up.The text begins with a review of the epidemiology and risk factors for PE. Chapters then delve into reviewing the decision pathways based on PE severity and treatment options, including the use of oral anticoagulation, systemic and catheter-directed thrombolysis, mechanical and surgical thrombectomy, and hemodynamic support with extracorporeal membrane oxygenation. The text then focuses on post-PE complications such as post-PE syndrome, chronic thromboembolic disease, and chronic thromboembolic pulmonary hypertension (CTEPH).This is an ideal guide for providers of lung health, including pulmonary and critical care physicians, cardiologists, thoracic and cardiovascular surgeons. Physician-trainees, physician assistants, nurses and respiratory therapists with interest in pulmonary disorders, cardiovascular disease, pulmonary embolism, critical care or pulmonary hypertension will also find great value in this comprehensive guide.
Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.
This book examines the most up-to-date strategies that can be used to enhance the healthcare professional-patient interaction to influence positive behavior change and improve treatment adherence in pulmonary healthcare. This book is written by experts in the field who couple their experience with practical strategies (the art) with evidence-based theory (the science).Chapters discuss global concepts such as motivational interviewing on improving engagement and how to apply strategies to specific situations (for examples: smoking cessation, promoting physical activity, inhaler adherence, supplemental oxygen use, and non-invasive ventilation) commonly experienced on the front lines of caring for patients with pulmonary disorders. The textbook raises awareness of direct approaches and recent technological advances that healthcare professionals can use to support positive behavior change in their day-to-day clinical practice. Effective, patient-tailored self-management interventions are discussed, including the evidence for these interventions and ways to personalize the strategies to each patient's unique needs.
This book is an ideal guide for healthcare professionals working with patients experiencing chronic pulmonary conditions, including pulmonologists, primary care physicians, physician assistants, nurses, trainees, and the many allied health professionals involved in delivering care such as respiratory therapists, pharmacists, and behavioral psychologists. The concepts of this book can also be applied to the management of other chronic diseases such as coronary artery disease and diabetes mellitus.
?This book incorporates a multi-disciplinary approach to present how research results can be translated into clinical trials. The first part begins with a chapter on variants of pancreatic cancer, precursor lesions and groups of people at risk to developing the disease. There is a particular focus on intraductal papillary mucinous neoplasia as a large-scale clinical challenge in pancreatology. The next two parts focus on diagnosis, biomarkers and stratification that emphasize how various approaches to biomarker development are important as both prognostic and predictive tools. The final part consists of personalized treatment approaches that include preclinical models of pancreatic cancer and stromal, epigenetic and metabolism targeting as promising approaches to be translated into early phase clinical trials. Chapters within this part also deal with approaches that are close to being implemented in clinical practice or are already being tested in (early) clinical trials, such as those that targeting the immune systems and strategies to overcome immunotherapy resistance; phase 1 clinical trials and translational approaches in surgical treatment.
Written by experts in their fields, Translational Pancreatic Cancer Research provides an outlook towards future directions by integrating information both from basic and clinical research and though demonstrating pathways to better understanding pancreatic cancer and current approaches to translating these into clinical practice.
The book is dedicated to Follicular lymphoma and Mantle cell lymphoma and highlights major reference works that contributed significantly to the understanding of these two lymphomas. The aim is to bring the basic science adjacent to the applied science. There is significant focus on the biology of normal B cell development that forms the basis for understanding the pathobiology of these entities. This text is designed to provide a concise yet comprehensive summary of traditional and newer entities, prognostic markers, pathobiology and newer classifications based on molecular genetics/chromosomal abnormalities. The chapters are written by practicing hematopathologists, molecular pathologists, dermatopathologists and clinical haematologists with an emphasis on practical approaches to these entities. The newer technologies and their practical applications are elaborated in an easy-to-comprehend format. Follicular Lymphoma and Mantle Cell Lymphoma is an approachable read for residents and fellows and clinically relevant to practicing pathologists and hematologists. It also serves as a valuable resource for anyone with an interest in B cell lymphomas.
A significantly expanded third edition, this book provides a comprehensive and concise overview of cardiac arrhythmias and their ECG/telemetry manifestations, including the principles of cardiac electrophysiology, current concepts of pharmacology, clinical features, diagnoses, and state-of-the-art treatments. Additionally, the book emphasizes decision-making strategies in approaching each individual patient and the application of technical innovations in specific clinical situations. Organized into eight parts, beginning chapters introduce the concepts and principles of cardiac electrophysiology, unique rhythms, and ECG waves/signs. These chapters are designed to integrate emerging knowledge in basic science and clinical medicine. Subsequent chapters focus on the diagnosis of a variety of cardiac arrhythmias using non-invasive methodology. Throughout the book, chapters continue to analyze pharmacological and other approaches to therapy of specific arrhythmias, including supraventricular tachycardias, atrial fibrillation and flutter, ventricular arrhythmias, and bradyarrhythmias. Finally, the book closes with coverage on inherited cardiac arrhythmia syndromes including the long, short QT, and J-wave syndromes, catecholaminergic polymorphic ventricular tachycardia, and arrhythmogenic right ventricular cardiomyopathy. The third edition of Management of Cardiac Arrhythmias, is an essential resource for physicians, residents, fellows, and medical students in cardiology, cardiac surgery, vascular surgery, cardiac electrophysiology, and cardiac radiology.
The book covers the basic science and clinical aspects of cardiovascular calcification and bone mineralization. Cardiovascular calcification is the leading predictor of cardiovascular morbidity and mortality, with a predictive value more significant than blood lipid levels. The presence of calcific mineral in cardiovascular tissues alters biomechanical performance, increasing workload on the heart and potentiating atherosclerotic plaque rupture and subsequent heart attack and stroke. This book examines the role of calcification in cardiovascular disease covering topics such as calcification in the atherosclerotic plaques and aortic valves arteries and valves, aortic valve replacement, peripheral artery disease, imaging of early calcification and target discovery. In addition, various forms of ectopic calcification as well as mechanisms of bone mineralization are discussed.
Cardiovascular Calcification and Bone Mineralization is an essential resource for clinicians, researchers, and other medical professionals in cardiology, pathology, and biomedical engineering.
This book comprehensively covers chronic lung disease and cardiovascular disease and their influence on one another including the epidemiology, physiology, risk factors, pathophysiology, clinical features, diagnostic issues including laboratory and imaging tests, and therapeutic considerations. How the diseases specifically overlap is explored in detail, covering presentation, symptoms, clinical examination findings, diagnostic test results, as well as a number of important medication interactions. The cardiovascular considerations in this book will include left ventricular systolic and diastolic dysfunction, pulmonary hypertension and right ventricular disease, as well as cardiac arrhythmias. The book also addresses extra-cardiac cardiovascular comorbidities such as cerebrovascular disease and peripheral arterial disease. Each chapter includes detailed illustrations as well as useful pearls and best practices, making this an ideal reference for pulmonologists, cardiologists, and residents caring for patients with increased risk for these comorbidities.
This book discusses the role of genes, oncogenes, anti-oncogenes, free radicals, PUFAs, anti-oxidants, lipid peroxidation process, telomere, and angiogenesis on the origin of cancer, cell proliferation, and cancer in general. It includes a broad introduction to cancer cells; genes, oncogenes, and anti-oncogenes; and free radicals. In later chapters, it discusses in depth the relationship among free radicals, lipid peroxidation and anti-oxidants in cell proliferation. It also discusses aerobic and anaerobic metabolism and their relationship to cancer, as well as the Warburg effect and its potential in the development of new targets for cancer management. Based on these and other evidences, Molecular Biochemical Aspects of Cancer introduces a novel concept that suggests that selective enhancement of free radical generation in tumor cells could form a strategy to induce apoptosis of cancer cells employing bioactive lipids. It presents a new method of treatment of cancer using in vitro, in vivo and clinical data. This book will interest oncologists, scientists, molecular biologists, life scientists.
This book provides a comprehensive overview of the multisystem disease, cystic fibrosis, for both pediatric and adult patients. Written by experts in the field, the text outlines the progressive nature of CF as well as the impact of this autosomal recessive disease on the respiratory, gastrointestinal, endocrine, rheumatologic, and renal systems, as well as the patient's mental health. The book begins with a chapter describing the history of cystic fibrosis and how the face of this life-shortening disease has changed over the past several decades. The following chapters elucidate the pathophysiology of how cystic fibrosis impacts each organ system. Current management and therapeutics are detailed with step-by-step guidelines for clinicians. This book is unique in that it highlights the entire person, not just the respiratory system, with detailed inclusion of the patient perspectives throughout, informing practice standards and considerations. This is an ideal guide for pediatric and adult physicians who care for patients with cystic fibrosis, as well as respiratory therapists, physical therapists, nurses, nutritionists, and pharmacists who care for these patients.
This book provides a thorough, multidisciplinary review of the latest research and clinical approaches in the field of sleep disorders. It illustrates the variance of complications, symptoms, and issues sleep disorders cause during different stages of a woman's life. This updated, comprehensive edition begins with an overview of sleep disorders in women, followed by a section dedicated to examining sleep disorders in women during adolescence. Subsequent chapters then focus on treating pregnant women with sleep disorders, which include conditions such as restless legs syndrome, that arise during the gestational period as well as those like narcolepsy, whose management offers unique challenges during pregnancy and lactation. The book concludes with information on the specific issues caused by sleep disorders faced by women during and after menopause. Sleep Disorders in Women, 3rd Edition serves as an important addition to the literature and is an invaluable resource for neurologists, sleep medicine specialists, OB/GYNs, internal medicine physicians, family practitioners, psychiatrists, nurse practitioners, and physician assistants.
This book is the first authoritative and comprehensive volume dedicated to epicardial adipose tissue (EAT). It provides an up-to-date and highly illustrated synopsis of the anatomical, biomolecular, genetic, imaging features, and clinical applications of EAT and its role in cardiovascular disease.It relays to the reader a contemporary view of the emerging interplay between the heart and adiposity-related diseases. In addition, this volume discusses the clinical implications and therapeutic targets of EAT in atrial fibrillation, heart failure and coronary artery disease.Comprehensive yet focused, Epicardial Adipose Tissue: From Cell to Clinic is an essential resource for physicians, residents, fellows, and medical students in cardiology, endocrinology, primary care, and health promotion and disease prevention.
This book offers valuable guidance to neurointensivists, other neurocritical care staff, and those desiring to develop a neurocritical care unit via a thorough discussion of neurological emergencies and neurocritical care unit organization.This comprehensive volume begins with a review of acute neurological emergencies as managed clinically in the neurocritical care unit. Topics include acute cerebrovascular, neurological, and neurosurgical disorders. The unique aspect of this book is its description of the organization of the neurocritical care unit. We focus on how other services in the hospital interact with and assist neurocritical care operations, telemedicine/telestroke, and neurocritical care personnel and their roles. A review of expected outcomes of neurocritical care conditions is also included.Neurointensivists, neurocritical care unit staff leadership, hospital administrators, and those interested in developing a neurocritical care unit will find Neurointensive Care Unit: Clinical Practice and Organization to be an invaluable guide.
Obstetrical care in the family medicine setting is an ever-evolving discipline. In addition to routine updates due to the passage of time, several new developments have occurred in the field since the last edition of this book was published. Among these developments are advances in prenatal assessment and diagnosis, recommendations for vaccination in pregnancy, assessment and management of infectious disease in pregnancy, and management of chronic disease concurrent with pregnancy.
All thirty-one chapters of the second edition of this text have been thoroughly updated. Several chapters warranted substantive expansion and revision due to the developments on the topic. These chapters include preconception counseling, prenatal care, dysmorphic growth, preterm labor, recurrent pregnancy loss, infection, diabetes, postdates, normal labor, induction and augmentation, prolonged labor, fetal heart rate monitoring, routine postpartum and complications postpartum. A new chapter has been added that covers vaccination in pregnancy as well as other routine wellness recommendations.
Now in its fully revised and expanded third edition, Obstetrics in Family Medicine reflects the significant changes that have occurred in the field since 2015. This book remains the definitive resource for meeting the needs of a wide range of primary care providers who provide direct or indirect care of patients of childbearing age. This book also appeals to nurse practitioners, physician assistants and nursing personnel working in the primary care setting. Additionally, this book serves as a useful guide for medical providers who intersect with pregnant, or possibly pregnant patients including emergency medicine physicians, surgeons, EMT's and paramedics.